RESEARCH OF INDICATORS OF OXIDATIVE STRESS IN THE KIDNEYS OF IMMATURE RATS WITH HYPERHOMOCYSTEINEMIA

Purpose: Hyperhomocysteinemia in children can develop as a result of genetic defects, endocrine abnormalities or under the influence dietary factors. An elevated level homocysteine is considered risk factor for progression chronic kidney disease. The aim work was to investigate indicators oxidative stress homogenate kidneys immature rats control and with hyperhomocysteinemia. Methods: concentration reduced oxidized glutathione, activity superoxide dismutase, catalase nitric oxide synthase were determined. model hyperhomocysteinemia reproduced on one-month-old male rats, which kept standard vivarium diet. experimental group intragastrically administered by D,L-thiolactone hydrochloride 1% starch solution at dose 200 mg/kg body weight 1 per day 8 weeks. corresponding volume injected into animals. determined spectrophotometrically. Concentration glutathione fluorometric method. Results: It established that upon catalase, decreased against background an increase rats. Conclusions: obtained results indicate development occurs direction characteristic adult resembles showed decrease antioxidant defense enzymes may pathological processes